BDBM28337 (1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[4-(methoxycarbonyl)-1H-imidazol-1-yl]ethyl})sulfonamido}-2-phenylcyclopropane-1-carboxylic acid::CHEMBL448604::US10322143, Shiozaki Compound 1::sulfonylamino-alkanecarboxylate, 51

SMILES: COC(=O)c1cn(CCN([C@@]2(C[C@H]2c2ccccc2)C(O)=O)S(=O)(=O)c2ccc(cc2)-c2ccc(Cl)cc2)cn1

InChI Key: InChIKey=CSUSVRGINZAUKG-ABYGYWHVSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 28337   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ADAMTS-5 (Aggrecanase-2) (Homo sapiens (Human))	BDBM28337 ((1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[4-(meth...) Show SMILES COC(=O)c1cn(CCN([C@@]2(C[C@H]2c2ccccc2)C(O)=O)S(=O)(=O)c2ccc(cc2)-c2ccc(Cl)cc2)cn1 |r| Show InChI InChI=1S/C29H26ClN3O6S/c1-39-27(34)26-18-32(19-31-26)15-16-33(29(28(35)36)17-25(29)22-5-3-2-4-6-22)40(37,38)24-13-9-21(10-14-24)20-7-11-23(30)12-8-20/h2-14,18-19,25H,15-17H2,1H3,(H,35,36)/t25-,29+/m0/s1	PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Japan Tobacco Inc.					Assay Description The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...				Bioorg Med Chem Lett 19: 1575-80 (2009) Article DOI: 10.1016/j.bmcl.2009.02.024 BindingDB Entry DOI: 10.7270/Q2PV6HPW
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human))	BDBM28337 ((1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[4-(meth...) Show SMILES COC(=O)c1cn(CCN([C@@]2(C[C@H]2c2ccccc2)C(O)=O)S(=O)(=O)c2ccc(cc2)-c2ccc(Cl)cc2)cn1 |r| Show InChI InChI=1S/C29H26ClN3O6S/c1-39-27(34)26-18-32(19-31-26)15-16-33(29(28(35)36)17-25(29)22-5-3-2-4-6-22)40(37,38)24-13-9-21(10-14-24)20-7-11-23(30)12-8-20/h2-14,18-19,25H,15-17H2,1H3,(H,35,36)/t25-,29+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca					Assay Description Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...				Bioorg Med Chem Lett 19: 4280-3 (2009) BindingDB Entry DOI: 10.7270/Q2BC41VN
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human))	BDBM28337 ((1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[4-(meth...) Show SMILES COC(=O)c1cn(CCN([C@@]2(C[C@H]2c2ccccc2)C(O)=O)S(=O)(=O)c2ccc(cc2)-c2ccc(Cl)cc2)cn1 |r| Show InChI InChI=1S/C29H26ClN3O6S/c1-39-27(34)26-18-32(19-31-26)15-16-33(29(28(35)36)17-25(29)22-5-3-2-4-6-22)40(37,38)24-13-9-21(10-14-24)20-7-11-23(30)12-8-20/h2-14,18-19,25H,15-17H2,1H3,(H,35,36)/t25-,29+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Central Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of ADAMTS5				Bioorg Med Chem Lett 19: 6213-7 (2009) Article DOI: 10.1016/j.bmcl.2009.08.093 BindingDB Entry DOI: 10.7270/Q2ZS2WMT
					More data for this Ligand-Target Pair