Reaction Details |
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Target | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
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Ligand | BDBM28337 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_619828 (CHEMBL1106705) |
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IC50 | 73±n/a nM |
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Citation | Shiozaki, M; Imai, H; Maeda, K; Miura, T; Yasue, K; Suma, A; Yokota, M; Ogoshi, Y; Haas, J; Fryer, AM; Laird, ER; Littmann, NM; Andrews, SW; Josey, JA; Mimura, T; Shinozaki, Y; Yoshiuchi, H; Inaba, T Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors. Bioorg Med Chem Lett19:6213-7 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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A disintegrin and metalloproteinase with thrombospondin motifs 5 |
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Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) | ADAMTS11 | ADAMTS5 | ADMP2 | ATS5_HUMAN | Aggrecanase-2 | Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) |
Type: | Enzyme |
Mol. Mass.: | 101769.09 |
Organism: | Homo sapiens (Human) |
Description: | Q9UNA0 |
Residue: | 930 |
Sequence: | MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH
PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT
SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR
VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD
QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR
LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR
NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK
CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV
QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
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BDBM28337 |
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n/a |
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Name | BDBM28337 |
Synonyms: | (1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[4-(methoxycarbonyl)-1H-imidazol-1-yl]ethyl})sulfonamido}-2-phenylcyclopropane-1-carboxylic acid | CHEMBL448604 | US10322143, Shiozaki Compound 1 | sulfonylamino-alkanecarboxylate, 51 |
Type | Small organic molecule |
Emp. Form. | C29H26ClN3O6S |
Mol. Mass. | 580.051 |
SMILES | COC(=O)c1cn(CCN([C@@]2(C[C@H]2c2ccccc2)C(O)=O)S(=O)(=O)c2ccc(cc2)-c2ccc(Cl)cc2)cn1 |r| |
Structure |
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