BDBM28648 ethyl 2-{[1-oxo-2-({[4-(trifluoromethoxy)phenyl]carbamoyl}methyl)-1,2-dihydroisoquinolin-5-yl]oxy}propanoate::isoquinolinone scaffold, 32

SMILES: CCOC(=O)C(C)Oc1cccc2c1ccn(CC(=O)Nc1ccc(OC(F)(F)F)cc1)c2=O

InChI Key: InChIKey=LKIPYCDCOCCGGK-UHFFFAOYSA-N

Data: 1 EC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28648   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Steroidogenic Factor 1 (Homo sapiens (Human))	BDBM28648 (ethyl 2-{[1-oxo-2-({[4-(trifluoromethoxy)phenyl]ca...) Show SMILES CCOC(=O)C(C)Oc1cccc2c1ccn(CC(=O)Nc1ccc(OC(F)(F)F)cc1)c2=O Show InChI InChI=1S/C23H21F3N2O6/c1-3-32-22(31)14(2)33-19-6-4-5-18-17(19)11-12-28(21(18)30)13-20(29)27-15-7-9-16(10-8-15)34-23(24,25)26/h4-12,14H,3,13H2,1-2H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Scripps Florida					Assay Description The assay was to monitor the SF-1 activation state via co-transfection of CHO-K1 cells with a plasmid encoding a Gal4-SF-1 chimerical transcription f...				Bioorg Med Chem Lett 18: 2628-32 (2008) Article DOI: 10.1016/j.bmcl.2008.03.027 BindingDB Entry DOI: 10.7270/Q2125R0M
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