BDBM291813 N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methyl-4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US9580437, Example 128
SMILES: Cc1cc(ccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12)S(C)(=O)=O
InChI Key: InChIKey=IPNXCHNXDBXYIB-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Polycomb Repressive Complex 2 (PRC2) (Homo sapiens (Human)) | BDBM291813 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb Repressive Complex 2 (PRC2) (Homo sapiens (Human)) | BDBM291813 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16.5 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291813 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291813 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291813 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 16.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb Repressive Complex 2 (PRC2) (Homo sapiens (Human)) | BDBM291813 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair |