BDBM292573 (S)-N-(2-(diethylamino)propyl)-2-((2-hydroxyethyl)amino)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 229

SMILES: CCN(CC)[C@@H](C)CNC(=O)c1cc(NCCO)nc(c1)-c1cnn2ccc(nc12)-c1cccs1

InChI Key: InChIKey=GDPJYKAZPVTGDH-KRWDZBQOSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 292573   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent protein kinase type II subunit delta (Homo sapiens (Human))	BDBM292573 ((S)-N-(2-(diethylamino)propyl)-2-((2-hydroxyethyl)...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(NCCO)nc(c1)-c1cnn2ccc(nc12)-c1cccs1 |r| Show InChI InChI=1S/C25H31N7O2S/c1-4-31(5-2)17(3)15-27-25(34)18-13-21(29-23(14-18)26-9-11-33)19-16-28-32-10-8-20(30-24(19)32)22-7-6-12-35-22/h6-8,10,12-14,16-17,33H,4-5,9,11,15H2,1-3H3,(H,26,29)(H,27,34)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta (Homo sapiens (Human))	BDBM292573 ((S)-N-(2-(diethylamino)propyl)-2-((2-hydroxyethyl)...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(NCCO)nc(c1)-c1cnn2ccc(nc12)-c1cccs1 |r| Show InChI InChI=1S/C25H31N7O2S/c1-4-31(5-2)17(3)15-27-25(34)18-13-21(29-23(14-18)26-9-11-33)19-16-28-32-10-8-20(30-24(19)32)22-7-6-12-35-22/h6-8,10,12-14,16-17,33H,4-5,9,11,15H2,1-3H3,(H,26,29)(H,27,34)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full length His-tagged CaMK2delta expressed in baculovirus using Biotin labelled STK1 as substrate after 1 hr in pres...				Citation and Details Article DOI: 10.1016/j.bmcl.2017.10.040 BindingDB Entry DOI: 10.7270/Q2930WR2
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta (Homo sapiens (Human))	BDBM292573 ((S)-N-(2-(diethylamino)propyl)-2-((2-hydroxyethyl)...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(NCCO)nc(c1)-c1cnn2ccc(nc12)-c1cccs1 |r| Show InChI InChI=1S/C25H31N7O2S/c1-4-31(5-2)17(3)15-27-25(34)18-13-21(29-23(14-18)26-9-11-33)19-16-28-32-10-8-20(30-24(19)32)22-7-6-12-35-22/h6-8,10,12-14,16-17,33H,4-5,9,11,15H2,1-3H3,(H,26,29)(H,27,34)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	34.6	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair