BDBM29834 spiro-carboxamide scaffold, 7

SMILES: Fc1ccc(cc1)C1(CC1)C(=O)N1CCC2(C1)CCCCC2

InChI Key: InChIKey=GAIHSEBPNVRXCW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 29834   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM29834 (spiro-carboxamide scaffold, 7) Show SMILES Fc1ccc(cc1)C1(CC1)C(=O)N1CCC2(C1)CCCCC2 Show InChI InChI=1S/C19H24FNO/c20-16-6-4-15(5-7-16)19(10-11-19)17(22)21-13-12-18(14-21)8-2-1-3-9-18/h4-7H,1-3,8-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	37
Merck-Serono					Assay Description 11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...				Bioorg Med Chem Lett 19: 3682-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.123 BindingDB Entry DOI: 10.7270/Q2X065DQ
					More data for this Ligand-Target Pair