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SMILES: NC1CCN(CC1)c1ncc(-c2cnn(CC3CCOC3)c2)c(n1)-c1ccc(cc1)C#N

InChI Key: InChIKey=MUDROINPSCCRCF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 301085   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))		BDBM301085
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[1- (oxolan-3-ylmet...)
Show SMILES NC1CCN(CC1)c1ncc(-c2cnn(CC3CCOC3)c2)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H27N7O/c25-11-17-1-3-19(4-2-17)23-22(13-27-24(29-23)30-8-5-21(26)6-9-30)20-12-28-31(15-20)14-18-7-10-32-16-18/h1-4,12-13,15,18,21H,5-10,14,16,26H2
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...

US Patent US10131664 (2018)


BindingDB Entry DOI: 10.7270/Q2JD4ZV1
More data for this
Ligand-Target Pair