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BDBM316162 2-{[3-({5-[3-(2,5,8,11,14-pentaoxahexadecane-16-yl)ureido]pyridine-2-yl}ethynyl)-1H-indazol-6-yl]thio}-N-methylbenzamide ::US9617222, Compound 37

SMILES: CNC(=O)c1ccccc1Sc1ccc2c(n[nH]c2c1)C#Cc1ccc(NC(=O)NCCOCCOCCOCCOCCOC)cn1

InChI Key: InChIKey=JBRNVUSGLAFGQA-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 316162   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM316162
PNG
(2-{[3-({5-[3-(2,5,8,11,14-pentaoxahexadecane-16-yl...)
Show SMILES CNC(=O)c1ccccc1Sc1ccc2c(n[nH]c2c1)C#Cc1ccc(NC(=O)NCCOCCOCCOCCOCCOC)cn1 |$;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;HN;;;;;;;;;;;;;;;;;;$|
Show InChI InChI=1S/C34H40N6O7S/c1-35-33(41)29-5-3-4-6-32(29)48-27-10-11-28-30(39-40-31(28)23-27)12-9-25-7-8-26(24-37-25)38-34(42)36-13-14-44-17-18-46-21-22-47-20-19-45-16-15-43-2/h3-8,10-11,23-24H,13-22H2,1-2H3,(H,35,41)(H,39,40)(H2,36,38,42)
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US Patent
n/an/a 5.90n/an/an/an/an/an/a



SENJU PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement of the kinase inhibitory activity of each compound produced in Examples was conducted using the Off-chip Mobility Shift Assay. For this t...

US Patent US9617222 (2017)


BindingDB Entry DOI: 10.7270/Q2FN189X
More data for this
Ligand-Target Pair