BDBM321150 US10174049, Example 17::US9738658, Example 17::US9796729, 19

SMILES: Nc1ncnc2OCCN(c3ccc4n(ccc4c3)-c3ccccc3OC3CCCC3)C(=O)c12

InChI Key: InChIKey=IQJHHPMHEXAHQP-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 321150   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM321150 (US10174049, Example 17 | US9738658, Example 17 | U...) Show SMILES Nc1ncnc2OCCN(c3ccc4n(ccc4c3)-c3ccccc3OC3CCCC3)C(=O)c12 Show InChI InChI=1S/C26H25N5O3/c27-24-23-25(29-16-28-24)33-14-13-30(26(23)32)18-9-10-20-17(15-18)11-12-31(20)21-7-3-4-8-22(21)34-19-5-1-2-6-19/h3-4,7-12,15-16,19H,1-2,5-6,13-14H2,(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Glaxosmithkline LLC US Patent					Assay Description For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...				US Patent US10174049 (2019) BindingDB Entry DOI: 10.7270/Q2X92DCR
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM321150 (US10174049, Example 17 | US9738658, Example 17 | U...) Show SMILES Nc1ncnc2OCCN(c3ccc4n(ccc4c3)-c3ccccc3OC3CCCC3)C(=O)c12 Show InChI InChI=1S/C26H25N5O3/c27-24-23-25(29-16-28-24)33-14-13-30(26(23)32)18-9-10-20-17(15-18)11-12-31(20)21-7-3-4-8-22(21)34-19-5-1-2-6-19/h3-4,7-12,15-16,19H,1-2,5-6,13-14H2,(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.2	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE LLC US Patent					Assay Description For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...				US Patent US9796729 (2017) BindingDB Entry DOI: 10.7270/Q2057J2H
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM321150 (US10174049, Example 17 | US9738658, Example 17 | U...) Show SMILES Nc1ncnc2OCCN(c3ccc4n(ccc4c3)-c3ccccc3OC3CCCC3)C(=O)c12 Show InChI InChI=1S/C26H25N5O3/c27-24-23-25(29-16-28-24)33-14-13-30(26(23)32)18-9-10-20-17(15-18)11-12-31(20)21-7-3-4-8-22(21)34-19-5-1-2-6-19/h3-4,7-12,15-16,19H,1-2,5-6,13-14H2,(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE LLC US Patent					Assay Description For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...				US Patent US9796729 (2017) BindingDB Entry DOI: 10.7270/Q2057J2H
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM321150 (US10174049, Example 17 | US9738658, Example 17 | U...) Show SMILES Nc1ncnc2OCCN(c3ccc4n(ccc4c3)-c3ccccc3OC3CCCC3)C(=O)c12 Show InChI InChI=1S/C26H25N5O3/c27-24-23-25(29-16-28-24)33-14-13-30(26(23)32)18-9-10-20-17(15-18)11-12-31(20)21-7-3-4-8-22(21)34-19-5-1-2-6-19/h3-4,7-12,15-16,19H,1-2,5-6,13-14H2,(H2,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline LLC US Patent					Assay Description For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...				US Patent US9738658 (2017) BindingDB Entry DOI: 10.7270/Q26Q20BZ
					More data for this Ligand-Target Pair