BDBM333405 5-(2,4-Difluorophenoxy)-6-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one::US9737516, Example 1

SMILES: Cn1cc(-c2cc3[nH]c(=O)[nH]c3cc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O

InChI Key: InChIKey=GWPMHMOGSQWLQC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 333405   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human))	BDBM333405 (5-(2,4-Difluorophenoxy)-6-(6-methyl-7-oxo-6,7-dihy...) Show SMILES Cn1cc(-c2cc3[nH]c(=O)[nH]c3cc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O Show InChI InChI=1S/C21H14F2N4O3/c1-27-9-13(11-4-5-24-19(11)20(27)28)12-7-15-16(26-21(29)25-15)8-18(12)30-17-3-2-10(22)6-14(17)23/h2-9,24H,1H3,(H2,25,26,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...				US Patent US9737516 (2017) BindingDB Entry DOI: 10.7270/Q2154K40
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [75-147] (Homo sapiens (Human))	BDBM333405 (5-(2,4-Difluorophenoxy)-6-(6-methyl-7-oxo-6,7-dihy...) Show SMILES Cn1cc(-c2cc3[nH]c(=O)[nH]c3cc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O Show InChI InChI=1S/C21H14F2N4O3/c1-27-9-13(11-4-5-24-19(11)20(27)28)12-7-15-16(26-21(29)25-15)8-18(12)30-17-3-2-10(22)6-14(17)23/h2-9,24H,1H3,(H2,25,26,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...				US Patent US9737516 (2017) BindingDB Entry DOI: 10.7270/Q2154K40
					More data for this Ligand-Target Pair