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SMILES: Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1Oc1ccc(cc1)C(O)=O

InChI Key: InChIKey=OULGGQYCBQOEMS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 337603   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Flap endonuclease 1


(Homo sapiens (Human))		BDBM337603
PNG
(4-{[4'-(5-Aminopyrazin-2-yl)-3'- fluorobiphenyl-2-...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1Oc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H16FN3O3/c24-19-11-15(7-10-18(19)20-12-27-22(25)13-26-20)17-3-1-2-4-21(17)30-16-8-5-14(6-9-16)23(28)29/h1-13H,(H2,25,27)(H,28,29)
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MMDB

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PC cid
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US Patent
 0.700n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...

US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair