BDBM34110 glucopyranosylidene-spiro-isoxazoline, 4e
SMILES: OC[C@H]1O[C@@]2(CC(=NO2)c2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O
InChI Key: InChIKey=YKACTKXMYNIMHP-UYTYNIKBSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glycogen Phosphorylase (PYGM) (Oryctolagus cuniculus (rabbit)) | BDBM34110 (glucopyranosylidene-spiro-isoxazoline, 4e) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 630 | -8.59 | n/a | n/a | n/a | n/a | n/a | 6.8 | 30 |
Universite de Lyon | Assay Description Phosphorylase activity was measured in the direction of glycogen synthesis by the release of orthophosphate from Glc-1-P. The enzyme was assayed in g... | Bioorg Med Chem 17: 7368-80 (2009) Article DOI: 10.1016/j.bmc.2009.08.060 BindingDB Entry DOI: 10.7270/Q28P5XV8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Glycogen phosphorylase, muscle form (Oryctolagus cuniculus (rabbit)) | BDBM34110 (glucopyranosylidene-spiro-isoxazoline, 4e) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lyon Curated by ChEMBL | Assay Description Binding affinity to rabbit muscular GPb by NMR binding assay | J Med Chem 55: 1287-95 (2012) Article DOI: 10.1021/jm201439b BindingDB Entry DOI: 10.7270/Q21J9BS9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Glycogen Phosphorylase (PYGL) (Homo sapiens (Human)) | BDBM34110 (glucopyranosylidene-spiro-isoxazoline, 4e) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Claude Bernard Lyon 1 Curated by ChEMBL | Assay Description Inhibition of glycogen phosphorylase in human hepatocytes assessed as glucagon stimulated glycogen content after 3 hrs by colorimetric GOD method | Eur J Med Chem 108: 444-54 (2016) BindingDB Entry DOI: 10.7270/Q2QR500M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver glycogen phosphorylase (Rattus norvegicus) | BDBM34110 (glucopyranosylidene-spiro-isoxazoline, 4e) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Claude Bernard Lyon 1 Curated by ChEMBL | Assay Description Inhibition of glycogen phosphorylase in Wistar rat hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxi... | Eur J Med Chem 108: 444-54 (2016) BindingDB Entry DOI: 10.7270/Q2QR500M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen Phosphorylase (PYGL) (Homo sapiens (Human)) | BDBM34110 (glucopyranosylidene-spiro-isoxazoline, 4e) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Claude Bernard Lyon 1 Curated by ChEMBL | Assay Description Inhibition of glycogen phosphorylase in human hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxidase ... | Eur J Med Chem 108: 444-54 (2016) BindingDB Entry DOI: 10.7270/Q2QR500M | |||||||||||
More data for this Ligand-Target Pair |