BDBM342101 3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-ethynyl-N-(2-morpholinoethyl)benzamide::US9771353, Example 1

SMILES: Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCN3CCOCC3)C#C)n2)c2ccccc12)C(C)(C)C

InChI Key: InChIKey=OPENPZCNOHPQNG-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 342101   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 12 (Homo sapiens (Human))	BDBM342101 (3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...) Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCN3CCOCC3)C#C)n2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C38H41N9O4/c1-6-25-21-26(35(48)39-15-16-47-17-19-50-20-18-47)23-27(22-25)41-36-40-14-13-34(44-36)51-31-12-11-30(28-9-7-8-10-29(28)31)42-37(49)43-33-24-32(38(2,3)4)45-46(33)5/h1,7-14,21-24H,15-20H2,2-5H3,(H,39,48)(H,40,41,44)(H2,42,43,49)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent					Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...				US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM342101 (3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...) Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCN3CCOCC3)C#C)n2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C38H41N9O4/c1-6-25-21-26(35(48)39-15-16-47-17-19-50-20-18-47)23-27(22-25)41-36-40-14-13-34(44-36)51-31-12-11-30(28-9-7-8-10-29(28)31)42-37(49)43-33-24-32(38(2,3)4)45-46(33)5/h1,7-14,21-24H,15-20H2,2-5H3,(H,39,48)(H,40,41,44)(H2,42,43,49)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	499	n/a	n/a	n/a	n/a	n/a	n/a
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...				US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM342101 (3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...) Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCN3CCOCC3)C#C)n2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C38H41N9O4/c1-6-25-21-26(35(48)39-15-16-47-17-19-50-20-18-47)23-27(22-25)41-36-40-14-13-34(44-36)51-31-12-11-30(28-9-7-8-10-29(28)31)42-37(49)43-33-24-32(38(2,3)4)45-46(33)5/h1,7-14,21-24H,15-20H2,2-5H3,(H,39,48)(H,40,41,44)(H2,42,43,49)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent					Assay Description GSK 3α: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determinin...				US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM342101 (3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...) Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCN3CCOCC3)C#C)n2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C38H41N9O4/c1-6-25-21-26(35(48)39-15-16-47-17-19-50-20-18-47)23-27(22-25)41-36-40-14-13-34(44-36)51-31-12-11-30(28-9-7-8-10-29(28)31)42-37(49)43-33-24-32(38(2,3)4)45-46(33)5/h1,7-14,21-24H,15-20H2,2-5H3,(H,39,48)(H,40,41,44)(H2,42,43,49)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent					Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...				US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219
					More data for this Ligand-Target Pair