BDBM342108 3-((4-((4-(3-(3-(tert-Butyl)-1-ethyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-ethynyl-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)benzamide::US9771353, Example 8

SMILES: CCn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCOCCOCCOC)C#C)n2)c2ccccc12)C(C)(C)C

InChI Key: InChIKey=WFIJSNHJXOWVOT-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 342108   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 12 (Homo sapiens (Human))	BDBM342108 (3-((4-((4-(3-(3-(tert-Butyl)-1-ethyl-1H-pyrazol-5-...) Show SMILES CCn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCOCCOCCOC)C#C)n2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C40H46N8O6/c1-7-27-23-28(37(49)41-17-18-52-21-22-53-20-19-51-6)25-29(24-27)43-38-42-16-15-36(46-38)54-33-14-13-32(30-11-9-10-12-31(30)33)44-39(50)45-35-26-34(40(3,4)5)47-48(35)8-2/h1,9-16,23-26H,8,17-22H2,2-6H3,(H,41,49)(H,42,43,46)(H2,44,45,50)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent					Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...				US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM342108 (3-((4-((4-(3-(3-(tert-Butyl)-1-ethyl-1H-pyrazol-5-...) Show SMILES CCn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCOCCOCCOC)C#C)n2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C40H46N8O6/c1-7-27-23-28(37(49)41-17-18-52-21-22-53-20-19-51-6)25-29(24-27)43-38-42-16-15-36(46-38)54-33-14-13-32(30-11-9-10-12-31(30)33)44-39(50)45-35-26-34(40(3,4)5)47-48(35)8-2/h1,9-16,23-26H,8,17-22H2,2-6H3,(H,41,49)(H,42,43,46)(H2,44,45,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against the GSK 3-alpha enzyme isoform (Invitrogen), are evaluated by determining the level o...				US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM342108 (3-((4-((4-(3-(3-(tert-Butyl)-1-ethyl-1H-pyrazol-5-...) Show SMILES CCn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCOCCOCCOC)C#C)n2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C40H46N8O6/c1-7-27-23-28(37(49)41-17-18-52-21-22-53-20-19-51-6)25-29(24-27)43-38-42-16-15-36(46-38)54-33-14-13-32(30-11-9-10-12-31(30)33)44-39(50)45-35-26-34(40(3,4)5)47-48(35)8-2/h1,9-16,23-26H,8,17-22H2,2-6H3,(H,41,49)(H,42,43,46)(H2,44,45,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent					Assay Description GSK 3α: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determinin...				US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM342108 (3-((4-((4-(3-(3-(tert-Butyl)-1-ethyl-1H-pyrazol-5-...) Show SMILES CCn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(cc(c3)C(=O)NCCOCCOCCOC)C#C)n2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C40H46N8O6/c1-7-27-23-28(37(49)41-17-18-52-21-22-53-20-19-51-6)25-29(24-27)43-38-42-16-15-36(46-38)54-33-14-13-32(30-11-9-10-12-31(30)33)44-39(50)45-35-26-34(40(3,4)5)47-48(35)8-2/h1,9-16,23-26H,8,17-22H2,2-6H3,(H,41,49)(H,42,43,46)(H2,44,45,50)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent					Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...				US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219
					More data for this Ligand-Target Pair