BDBM342165 4-[4-[5-[3-(difluoromethoxy)phenyl]- 4H-1,2,4-triazol-3-yl]-1-piperidyl]-6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidine::US9771369, Compound P-3204

SMILES: FC(F)Oc1cccc(c1)-c1nnc([nH]1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1

InChI Key: InChIKey=NJLGGIIYZXZGRH-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 342165   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Kit (Kit)(D816V) (Homo sapiens (Human))	BDBM342165 (4-[4-[5-[3-(difluoromethoxy)phenyl]- 4H-1,2,4-tria...) Show SMILES FC(F)Oc1cccc(c1)-c1nnc([nH]1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C26H22F3N7O/c27-18-6-4-15(5-7-18)21-13-20-24(32-21)30-14-31-25(20)36-10-8-16(9-11-36)22-33-23(35-34-22)17-2-1-3-19(12-17)37-26(28)29/h1-7,12-14,16,26H,8-11H2,(H,30,31,32)(H,33,34,35)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342165 (4-[4-[5-[3-(difluoromethoxy)phenyl]- 4H-1,2,4-tria...) Show SMILES FC(F)Oc1cccc(c1)-c1nnc([nH]1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C26H22F3N7O/c27-18-6-4-15(5-7-18)21-13-20-24(32-21)30-14-31-25(20)36-10-8-16(9-11-36)22-33-23(35-34-22)17-2-1-3-19(12-17)37-26(28)29/h1-7,12-14,16,26H,8-11H2,(H,30,31,32)(H,33,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair