BDBM346075 4-{2-[1,6-Dimethyl-2- (3-trifluoromethyl- phenyl)-1H- benzoimidazol-5- ylamino]-thiazol-4- yl}-benzonitrile::US10202370, Example 114

SMILES: Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cccc(c1)C(F)(F)F

InChI Key: InChIKey=GXJYPPMVYDZNLF-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 346075   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM346075 (4-{2-[1,6-Dimethyl-2- (3-trifluoromethyl- phenyl)-...) Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C26H18F3N5S/c1-15-10-23-21(31-24(34(23)2)18-4-3-5-19(11-18)26(27,28)29)12-20(15)32-25-33-22(14-35-25)17-8-6-16(13-30)7-9-17/h3-12,14H,1-2H3,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a
AB SCIENCE US Patent					Assay Description Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat N°G8081) was performed on BaF3 Kit WT cell lin...				US Patent US10202370 (2019) BindingDB Entry DOI: 10.7270/Q2Q52RRK
					More data for this Ligand-Target Pair