Found 8 hits for monomerid = 346173 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM346173
(US10202371, Example 3)Show SMILES COc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C24H24F3N7O5/c1-37-14-4-2-13(3-5-14)19-17(12-35)34(23(36)39-19)18-10-16(30-22(31-18)33-6-8-38-9-7-33)15-11-29-21(28)32-20(15)24(25,26)27/h2-5,10-11,17,19,35H,6-9,12H2,1H3,(H2,28,29,32)/t17-,19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM346173
(US10202371, Example 3)Show SMILES COc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C24H24F3N7O5/c1-37-14-4-2-13(3-5-14)19-17(12-35)34(23(36)39-19)18-10-16(30-22(31-18)33-6-8-38-9-7-33)15-11-29-21(28)32-20(15)24(25,26)27/h2-5,10-11,17,19,35H,6-9,12H2,1H3,(H2,28,29,32)/t17-,19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM346173
(US10202371, Example 3)Show SMILES COc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C24H24F3N7O5/c1-37-14-4-2-13(3-5-14)19-17(12-35)34(23(36)39-19)18-10-16(30-22(31-18)33-6-8-38-9-7-33)15-11-29-21(28)32-20(15)24(25,26)27/h2-5,10-11,17,19,35H,6-9,12H2,1H3,(H2,28,29,32)/t17-,19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Mus musculus (Mouse)) | BDBM346173
(US10202371, Example 3)Show SMILES COc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C24H24F3N7O5/c1-37-14-4-2-13(3-5-14)19-17(12-35)34(23(36)39-19)18-10-16(30-22(31-18)33-6-8-38-9-7-33)15-11-29-21(28)32-20(15)24(25,26)27/h2-5,10-11,17,19,35H,6-9,12H2,1H3,(H2,28,29,32)/t17-,19-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM346173
(US10202371, Example 3)Show SMILES COc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C24H24F3N7O5/c1-37-14-4-2-13(3-5-14)19-17(12-35)34(23(36)39-19)18-10-16(30-22(31-18)33-6-8-38-9-7-33)15-11-29-21(28)32-20(15)24(25,26)27/h2-5,10-11,17,19,35H,6-9,12H2,1H3,(H2,28,29,32)/t17-,19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
TR-FRET assays for protein kinases uses a long-lifetime lanthanide Terbium or Europium chelates as the donor species which overcome interference by c... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Rattus norvegicus (Rat)) | BDBM346173
(US10202371, Example 3)Show SMILES COc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C24H24F3N7O5/c1-37-14-4-2-13(3-5-14)19-17(12-35)34(23(36)39-19)18-10-16(30-22(31-18)33-6-8-38-9-7-33)15-11-29-21(28)32-20(15)24(25,26)27/h2-5,10-11,17,19,35H,6-9,12H2,1H3,(H2,28,29,32)/t17-,19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Rattus norvegicus (Rat)) | BDBM346173
(US10202371, Example 3)Show SMILES COc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C24H24F3N7O5/c1-37-14-4-2-13(3-5-14)19-17(12-35)34(23(36)39-19)18-10-16(30-22(31-18)33-6-8-38-9-7-33)15-11-29-21(28)32-20(15)24(25,26)27/h2-5,10-11,17,19,35H,6-9,12H2,1H3,(H2,28,29,32)/t17-,19-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM346173
(US10202371, Example 3)Show SMILES COc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C24H24F3N7O5/c1-37-14-4-2-13(3-5-14)19-17(12-35)34(23(36)39-19)18-10-16(30-22(31-18)33-6-8-38-9-7-33)15-11-29-21(28)32-20(15)24(25,26)27/h2-5,10-11,17,19,35H,6-9,12H2,1H3,(H2,28,29,32)/t17-,19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
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