BDBM346366 US10202377, Compound 940

SMILES: Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccc(F)c1

InChI Key: InChIKey=HMCVPMKLOIMAPY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 346366   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM346366 (US10202377, Compound 940) Show SMILES Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cccc(F)c1 Show InChI InChI=1S/C23H16FN7/c1-31-12-14(10-26-31)19-9-17-20(11-25-19)29-30-22(17)23-27-18-7-3-6-16(21(18)28-23)13-4-2-5-15(24)8-13/h2-12H,1H3,(H,27,28)(H,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...				US Patent US10202377 (2019) BindingDB Entry DOI: 10.7270/Q2639RV7
					More data for this Ligand-Target Pair