null

SMILES: Fc1cccc(NC(=O)COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1

InChI Key: InChIKey=NFWZCVLUMYWRPC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 348998   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 [781-1124] (Homo sapiens (Human))	BDBM348998 (N-(5-(4-(2-(3- fluorophenylamino)-2- oxoethoxy)phe...) Show SMILES Fc1cccc(NC(=O)COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1 Show InChI InChI=1S/C24H20FN5O3/c25-17-3-1-4-18(13-17)26-22(31)14-33-19-11-9-15(10-12-19)20-5-2-6-21-27-24(29-30(20)21)28-23(32)16-7-8-16/h1-6,9-13,16H,7-8,14H2,(H,26,31)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM348998 (N-(5-(4-(2-(3- fluorophenylamino)-2- oxoethoxy)phe...) Show SMILES Fc1cccc(NC(=O)COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1 Show InChI InChI=1S/C24H20FN5O3/c25-17-3-1-4-18(13-17)26-22(31)14-33-19-11-9-15(10-12-19)20-5-2-6-21-27-24(29-30(20)21)28-23(32)16-7-8-16/h1-6,9-13,16H,7-8,14H2,(H,26,31)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Homo sapiens (Human))	BDBM348998 (N-(5-(4-(2-(3- fluorophenylamino)-2- oxoethoxy)phe...) Show SMILES Fc1cccc(NC(=O)COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1 Show InChI InChI=1S/C24H20FN5O3/c25-17-3-1-4-18(13-17)26-22(31)14-33-19-11-9-15(10-12-19)20-5-2-6-21-27-24(29-30(20)21)28-23(32)16-7-8-16/h1-6,9-13,16H,7-8,14H2,(H,26,31)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Homo sapiens (Human))	BDBM348998 (N-(5-(4-(2-(3- fluorophenylamino)-2- oxoethoxy)phe...) Show SMILES Fc1cccc(NC(=O)COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1 Show InChI InChI=1S/C24H20FN5O3/c25-17-3-1-4-18(13-17)26-22(31)14-33-19-11-9-15(10-12-19)20-5-2-6-21-27-24(29-30(20)21)28-23(32)16-7-8-16/h1-6,9-13,16H,7-8,14H2,(H,26,31)(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...				US Patent US10206907 (2019) BindingDB Entry DOI: 10.7270/Q23J3G3B
					More data for this Ligand-Target Pair