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SMILES: NC(=O)C1CCCC(C1)Nc1ncc(c(Nc2ccccc2NC(=O)C=C)n1)C(F)(F)F

InChI Key: InChIKey=GMDKMWSVDWXFDY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350908   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 3


(Homo sapiens (Human))		BDBM350908
PNG
(US9796700, Compound I-2)
Show SMILES NC(=O)C1CCCC(C1)Nc1ncc(c(Nc2ccccc2NC(=O)C=C)n1)C(F)(F)F
Show InChI InChI=1S/C21H23F3N6O2/c1-2-17(31)28-15-8-3-4-9-16(15)29-19-14(21(22,23)24)11-26-20(30-19)27-13-7-5-6-12(10-13)18(25)32/h2-4,8-9,11-13H,1,5-7,10H2,(H2,25,32)(H,28,31)(H2,26,27,29,30)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
The protocol below describes continuous-read kinase assays to measure potency of compounds against activated ERK1 enzyme. The mechanics of the assay ...

US Patent US9796700 (2017)


BindingDB Entry DOI: 10.7270/Q2J38VQD
More data for this
Ligand-Target Pair