BDBM351407 1,4:3,6-dianhydro-5-O-[4-{[3-bromo-5- (trifluoromethyl)phenyl]amino}-6- (methyloxy)quinazolin-7-yl]-2-deoxy-2-fluoro- D-iditol::US9796704, Entry 127

SMILES: COc1cc2c(Nc3cc(Br)cc(c3)C(F)(F)F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12

InChI Key: InChIKey=FSSHDIKQMARYSU-FCDRMGDPSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 351407   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM351407 (1,4:3,6-dianhydro-5-O-[4-{[3-bromo-5- (trifluorome...) Show SMILES COc1cc2c(Nc3cc(Br)cc(c3)C(F)(F)F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12 |r| Show InChI InChI=1S/C22H18BrF4N3O4/c1-31-16-5-13-15(6-17(16)34-18-8-33-19-14(24)7-32-20(18)19)28-9-29-21(13)30-12-3-10(22(25,26)27)2-11(23)4-12/h2-6,9,14,18-20H,7-8H2,1H3,(H,28,29,30)/t14-,18-,19+,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 (Homo sapiens (Human))	BDBM351407 (1,4:3,6-dianhydro-5-O-[4-{[3-bromo-5- (trifluorome...) Show SMILES COc1cc2c(Nc3cc(Br)cc(c3)C(F)(F)F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12 |r| Show InChI InChI=1S/C22H18BrF4N3O4/c1-31-16-5-13-15(6-17(16)34-18-8-33-19-14(24)7-32-20(18)19)28-9-29-21(13)30-12-3-10(22(25,26)27)2-11(23)4-12/h2-6,9,14,18-20H,7-8H2,1H3,(H,28,29,30)/t14-,18-,19+,20+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM351407 (1,4:3,6-dianhydro-5-O-[4-{[3-bromo-5- (trifluorome...) Show SMILES COc1cc2c(Nc3cc(Br)cc(c3)C(F)(F)F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12 |r| Show InChI InChI=1S/C22H18BrF4N3O4/c1-31-16-5-13-15(6-17(16)34-18-8-33-19-14(24)7-32-20(18)19)28-9-29-21(13)30-12-3-10(22(25,26)27)2-11(23)4-12/h2-6,9,14,18-20H,7-8H2,1H3,(H,28,29,30)/t14-,18-,19+,20+/m1/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM351407 (1,4:3,6-dianhydro-5-O-[4-{[3-bromo-5- (trifluorome...) Show SMILES COc1cc2c(Nc3cc(Br)cc(c3)C(F)(F)F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12 |r| Show InChI InChI=1S/C22H18BrF4N3O4/c1-31-16-5-13-15(6-17(16)34-18-8-33-19-14(24)7-32-20(18)19)28-9-29-21(13)30-12-3-10(22(25,26)27)2-11(23)4-12/h2-6,9,14,18-20H,7-8H2,1H3,(H,28,29,30)/t14-,18-,19+,20+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM351407 (1,4:3,6-dianhydro-5-O-[4-{[3-bromo-5- (trifluorome...) Show SMILES COc1cc2c(Nc3cc(Br)cc(c3)C(F)(F)F)ncnc2cc1O[C@@H]1CO[C@H]2[C@H](F)CO[C@@H]12 |r| Show InChI InChI=1S/C22H18BrF4N3O4/c1-31-16-5-13-15(6-17(16)34-18-8-33-19-14(24)7-32-20(18)19)28-9-29-21(13)30-12-3-10(22(25,26)27)2-11(23)4-12/h2-6,9,14,18-20H,7-8H2,1H3,(H,28,29,30)/t14-,18-,19+,20+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair