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SMILES: COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1noc(n1)-c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=PTLHFHNCPGNWKH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 351447   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM351447 (N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({5- [4-(t...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1noc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H16Cl2F3N5O3/c1-36-20-9-16-19(31-12-32-23(16)33-15-6-7-17(26)18(27)8-15)10-21(20)37-11-22-34-24(38-35-22)13-2-4-14(5-3-13)25(28,29)30/h2-10,12H,11H2,1H3,(H,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 (Homo sapiens (Human))	BDBM351447 (N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({5- [4-(t...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1noc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H16Cl2F3N5O3/c1-36-20-9-16-19(31-12-32-23(16)33-15-6-7-17(26)18(27)8-15)10-21(20)37-11-22-34-24(38-35-22)13-2-4-14(5-3-13)25(28,29)30/h2-10,12H,11H2,1H3,(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM351447 (N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({5- [4-(t...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1noc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H16Cl2F3N5O3/c1-36-20-9-16-19(31-12-32-23(16)33-15-6-7-17(26)18(27)8-15)10-21(20)37-11-22-34-24(38-35-22)13-2-4-14(5-3-13)25(28,29)30/h2-10,12H,11H2,1H3,(H,31,32,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM351447 (N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({5- [4-(t...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1noc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H16Cl2F3N5O3/c1-36-20-9-16-19(31-12-32-23(16)33-15-6-7-17(26)18(27)8-15)10-21(20)37-11-22-34-24(38-35-22)13-2-4-14(5-3-13)25(28,29)30/h2-10,12H,11H2,1H3,(H,31,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM351447 (N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({5- [4-(t...) Show SMILES COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCc1noc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H16Cl2F3N5O3/c1-36-20-9-16-19(31-12-32-23(16)33-15-6-7-17(26)18(27)8-15)10-21(20)37-11-22-34-24(38-35-22)13-2-4-14(5-3-13)25(28,29)30/h2-10,12H,11H2,1H3,(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	525	n/a	n/a	n/a	n/a	n/a	n/a
SYMPHONY EVOLUTION, INC. US Patent					Assay Description In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...				US Patent US9796704 (2017) BindingDB Entry DOI: 10.7270/Q28K7C6V
					More data for this Ligand-Target Pair