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BDBM354716 Preparation of 4-((2R,5S)-5-((3-methoxyphenoxy)methyl)-2-(trifluoromethyl)oxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile::US9809583, Example 28

SMILES: COc1cccc(OC[C@@H]2CN([C@H](O2)C(F)(F)F)c2ccc(C#N)c(c2)C(F)(F)F)c1

InChI Key: InChIKey=SRLFSFKUNRQJAQ-FUHWJXTLSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 354716   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Androgen Receptor


(Chlorocebus sabaeus (Green monkey) (Cercopithecus ...)		BDBM354716
PNG
(Preparation of 4-((2R,5S)-5-((3-methoxyphenoxy)met...)
Show SMILES COc1cccc(OC[C@@H]2CN([C@H](O2)C(F)(F)F)c2ccc(C#N)c(c2)C(F)(F)F)c1 |r|
Show InChI InChI=1S/C20H16F6N2O3/c1-29-14-3-2-4-15(8-14)30-11-16-10-28(18(31-16)20(24,25)26)13-6-5-12(9-27)17(7-13)19(21,22)23/h2-8,16,18H,10-11H2,1H3/t16-,18+/m0/s1
PDB

UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a 77.2n/an/an/an/an/an/a



DONG-A ST CO., LTD.

US Patent


Assay Description
In order to examine binding ability of the agonists of the present invention to androgen receptors, the following in-vitro experiment was performed. ...

US Patent US9809583 (2017)


BindingDB Entry DOI: 10.7270/Q2C82CGC
More data for this
Ligand-Target Pair