BDBM355853 4-ethoxy-N-(3-fluoro-4-((5-pyridin-4-yl)pyrrolo[1,2-b]pyridazin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridin-3-carboxamide::US9815840, Example 7

SMILES: CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnn3ccc(-c4ccncc4)c23)c(F)c1

InChI Key: InChIKey=ZBZGDBFDJRPKDH-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 355853   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM355853 (4-ethoxy-N-(3-fluoro-4-((5-pyridin-4-yl)pyrrolo[1,...) Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnn3ccc(-c4ccncc4)c23)c(F)c1 Show InChI InChI=1S/C32H23F2N5O4/c1-2-42-27-13-17-38(23-6-3-21(33)4-7-23)32(41)29(27)31(40)37-22-5-8-26(25(34)19-22)43-28-11-16-36-39-18-12-24(30(28)39)20-9-14-35-15-10-20/h3-19H,2H2,1H3,(H,37,40)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
The Asan Foundation US Patent					Assay Description The inhibitory effect of the compounds of the present invention on the activity of c-Met was confirmed as follows.Specifically, 250 μM G4Y1 pept...				US Patent US9815840 (2017) BindingDB Entry DOI: 10.7270/Q2862JQZ
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