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SMILES: Nc1cc(cc(c1)-c1ccn2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)c12)C#N

InChI Key: InChIKey=QXJBVLPXPGJFTP-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 355864   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM355864
PNG
(N-(4-((5-(3-amino-5-cyanophenyl)pyrrolo[1,2-b]pyri...)
Show SMILES Nc1cc(cc(c1)-c1ccn2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)c12)C#N
Show InChI InChI=1S/C31H22F2N6O3/c32-20-1-3-22(4-2-20)37-29(40)31(9-10-31)30(41)38-23-5-6-26(25(33)16-23)42-27-7-11-36-39-12-8-24(28(27)39)19-13-18(17-34)14-21(35)15-19/h1-8,11-16H,9-10,35H2,(H,37,40)(H,38,41)
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KEGG

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US Patent
n/an/a<40n/an/an/an/an/an/a



The Asan Foundation

US Patent


Assay Description
The inhibitory effect of the compounds of the present invention on the activity of c-Met was confirmed as follows.Specifically, 250 μM G4Y1 pept...

US Patent US9815840 (2017)


BindingDB Entry DOI: 10.7270/Q2862JQZ
More data for this
Ligand-Target Pair