BDBM355894 1-(5-chloro-6- methoxypyridin-3- yl)-3-(2-chloro-7- isopropylpyrazolo[1, 5-a]pyrimidin-6- yl)urea::US10442808, Example 18::US9815842, Example 18

SMILES: COc1ncc(NC(=O)Nc2cnc3cc(Cl)nn3c2C(C)C)cc1Cl

InChI Key: InChIKey=UJQDOHWUFHHMEA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355894   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)(aa 329-824) (Homo sapiens (Human))	BDBM355894 (1-(5-chloro-6- methoxypyridin-3- yl)-3-(2-chloro-7...) Show SMILES COc1ncc(NC(=O)Nc2cnc3cc(Cl)nn3c2C(C)C)cc1Cl Show InChI InChI=1S/C16H16Cl2N6O2/c1-8(2)14-11(7-19-13-5-12(18)23-24(13)14)22-16(25)21-9-4-10(17)15(26-3)20-6-9/h4-8H,1-3H3,(H2,21,22,25)	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...				US Patent US10442808 (2019) BindingDB Entry DOI: 10.7270/Q2S75JQ3
					More data for this Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM355894 (1-(5-chloro-6- methoxypyridin-3- yl)-3-(2-chloro-7...) Show SMILES COc1ncc(NC(=O)Nc2cnc3cc(Cl)nn3c2C(C)C)cc1Cl Show InChI InChI=1S/C16H16Cl2N6O2/c1-8(2)14-11(7-19-13-5-12(18)23-24(13)14)22-16(25)21-9-4-10(17)15(26-3)20-6-9/h4-8H,1-3H3,(H2,21,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...				US Patent US9815842 (2017) BindingDB Entry DOI: 10.7270/Q24F1T0N
					More data for this Ligand-Target Pair