BindingDB PrimarySearch

BDBM36460 3-Benzyl-4-(6-(cyclohexylmethyl)picolinamido)benzoic acid, 2::CID42628632::DD2

SMILES: OC(=O)c1ccc(NC(=O)c2cccc(CC3CCCCC3)n2)c(Cc2ccccc2)c1

InChI Key: InChIKey=QBZUPKMHCWADDF-UHFFFAOYSA-N

Data: 4 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 36460
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kaposi's sarcoma-associated herpesvirus (KSHV) (Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-...)	BDBM36460 (3-Benzyl-4-(6-(cyclohexylmethyl)picolinamido)benzo...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	8.0	30
University of California, San Francisco					Assay Description Human herpesvirus assay using human Kaposi's sarcoma-associated herpesvirus protease (KSHV Pr).				Nat Chem Biol 5: 640-6 (2009) Article DOI: 10.1038/nchembio.192 BindingDB Entry DOI: 10.7270/Q2RF5SC8
University of California, San Francisco					More data for this Ligand-Target Pair
Epstein-Barr virus protease (EBV Pr) (Human herpesvirus 4)	BDBM36460 (3-Benzyl-4-(6-(cyclohexylmethyl)picolinamido)benzo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a	8.0	n/a
University of California at San Francisco					Assay Description Compounds were prepared in 100% DMSO from 10 to 0.156 mM and/or from 5 to 0.078 mM. The P6 substrate concentrations were 5, 65, and 150 �M for KSHV, ...				Biochemistry 53: 4648-60 (2014) Article DOI: 10.1021/bi5003234 BindingDB Entry DOI: 10.7270/Q2WH2NQW
University of California at San Francisco					More data for this Ligand-Target Pair
Human cytomegalovirus protease (HCMV Pr) (Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)	BDBM36460 (3-Benzyl-4-(6-(cyclohexylmethyl)picolinamido)benzo...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	8.0	n/a
University of California at San Francisco					Assay Description Compounds were prepared in 100% DMSO from 10 to 0.156 mM and/or from 5 to 0.078 mM. The P6 substrate concentrations were 5, 65, and 150 �M for KSHV, ...				Biochemistry 53: 4648-60 (2014) Article DOI: 10.1021/bi5003234 BindingDB Entry DOI: 10.7270/Q2WH2NQW
University of California at San Francisco					More data for this Ligand-Target Pair
Kaposi's sarcoma-associated herpesvirus protease (KSHV Pr) (Human herpesvirus 8)	BDBM36460 (3-Benzyl-4-(6-(cyclohexylmethyl)picolinamido)benzo...) Show SMILES Show InChI	MMDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	8.0	n/a
University of California at San Francisco					Assay Description Compounds were prepared in 100% DMSO from 10 to 0.156 mM and/or from 5 to 0.078 mM. The P6 substrate concentrations were 5, 65, and 150 �M for KSHV, ...				Biochemistry 53: 4648-60 (2014) Article DOI: 10.1021/bi5003234 BindingDB Entry DOI: 10.7270/Q2WH2NQW
University of California at San Francisco					More data for this Ligand-Target Pair