BDBM365232 (2-Pyrrolidin-1-yl-6-pyr- rolidin-3-yl-pyrimidin- 4-yl)-(4-trifluoromethyl- pyridin-2-yl)-amine::US9868720, No. 66

SMILES: FC(F)(F)c1ccnc(Nc2cc(nc(n2)N2CCCC2)C2CCNC2)c1

InChI Key: InChIKey=AAFDZNCZUQRXIO-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 365232   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM365232 ((2-Pyrrolidin-1-yl-6-pyr- rolidin-3-yl-pyrimidin- ...) Show SMILES FC(F)(F)c1ccnc(Nc2cc(nc(n2)N2CCCC2)C2CCNC2)c1 Show InChI InChI=1S/C18H21F3N6/c19-18(20,21)13-4-6-23-15(9-13)25-16-10-14(12-3-5-22-11-12)24-17(26-16)27-7-1-2-8-27/h4,6,9-10,12,22H,1-3,5,7-8,11H2,(H,23,24,25,26)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2J38VWN
					More data for this Ligand-Target Pair