BDBM365281 1-Methyl-4-[2-(2-methyl- pyrrolidin-1-yl)-6-(4- trifluoromethyl-pyridin- 2-ylamino)-pyrimidin- 4-yl]-piperidin-2-one::US9868720, No. 332

SMILES: CC1CCCN1c1nc(Nc2cc(ccn2)C(F)(F)F)cc(n1)C1CCN(C)C(=O)C1

InChI Key: InChIKey=ZYCORHIZCJROQO-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 365281   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM365281 (1-Methyl-4-[2-(2-methyl- pyrrolidin-1-yl)-6-(4- tr...) Show SMILES CC1CCCN1c1nc(Nc2cc(ccn2)C(F)(F)F)cc(n1)C1CCN(C)C(=O)C1 Show InChI InChI=1S/C21H25F3N6O/c1-13-4-3-8-30(13)20-26-16(14-6-9-29(2)19(31)10-14)12-18(28-20)27-17-11-15(5-7-25-17)21(22,23)24/h5,7,11-14H,3-4,6,8-10H2,1-2H3,(H,25,26,27,28)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2J38VWN
					More data for this Ligand-Target Pair