BDBM365292 US9868720, No. 388::{2-(2-Methyl-2H-pyrazol- 3-yl)-6-[1-(tetrahydro- pyran-4-ylmethyl)- pyrrolidin-3-yl]-pyrimidin- 4-yl]-(4-trifluoromethyl- pyridin-2-yl)-amine
SMILES: Cn1nccc1-c1nc(Nc2cc(ccn2)C(F)(F)F)cc(n1)C1CCN(CC2CCOCC2)C1
InChI Key: InChIKey=KXZPWPPJOKEBOG-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human)) | BDBM365292 (US9868720, No. 388 | {2-(2-Methyl-2H-pyrazol- 3-yl...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8.75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen | Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina... | J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2J38VWN | |||||||||||
More data for this Ligand-Target Pair |