BDBM365302 US9868720, No. 423::{2-(1-Methyl-1H-pyrazol- 4-yl)-6-[1-(tetrahydro- pyran-4-ylmethyl)-pyrrolidin- 3-yl]-pyrimidin-4- yl}-(4-trifluoromethyl- pyridin-2-yl)-amine

SMILES: Cn1cc(cn1)-c1nc(Nc2cc(ccn2)C(F)(F)F)cc(n1)C1CCN(CC2CCOCC2)C1

InChI Key: InChIKey=UZXCTSFKUZQUOO-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 365302   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM365302 (US9868720, No. 423 | {2-(1-Methyl-1H-pyrazol- 4-yl...) Show SMILES Cn1cc(cn1)-c1nc(Nc2cc(ccn2)C(F)(F)F)cc(n1)C1CCN(CC2CCOCC2)C1 Show InChI InChI=1S/C24H28F3N7O/c1-33-14-18(12-29-33)23-30-20(17-3-7-34(15-17)13-16-4-8-35-9-5-16)11-22(32-23)31-21-10-19(2-6-28-21)24(25,26)27/h2,6,10-12,14,16-17H,3-5,7-9,13,15H2,1H3,(H,28,30,31,32)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2J38VWN
					More data for this Ligand-Target Pair