null

SMILES: OCC1(CCN(CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)NC3CCN(CC3)C3CCCC3)nc12)c1ccc(Cl)cc1

InChI Key: InChIKey=CUDGQJAWUZBIQT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366683   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366683 (4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1- p...) Show SMILES OCC1(CCN(CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)NC3CCN(CC3)C3CCCC3)nc12)c1ccc(Cl)cc1 Show InChI InChI=1S/C35H42ClN7O2/c36-27-11-9-26(10-12-27)35(24-44)17-22-42(23-18-35)31-6-3-19-43-32(31)39-34(40-43)38-28-13-7-25(8-14-28)33(45)37-29-15-20-41(21-16-29)30-4-1-2-5-30/h3,6-14,19,29-30,44H,1-2,4-5,15-18,20-24H2,(H,37,45)(H,38,40)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM366683 (4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1- p...) Show SMILES OCC1(CCN(CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)NC3CCN(CC3)C3CCCC3)nc12)c1ccc(Cl)cc1 Show InChI InChI=1S/C35H42ClN7O2/c36-27-11-9-26(10-12-27)35(24-44)17-22-42(23-18-35)31-6-3-19-43-32(31)39-34(40-43)38-28-13-7-25(8-14-28)33(45)37-29-15-20-41(21-16-29)30-4-1-2-5-30/h3,6-14,19,29-30,44H,1-2,4-5,15-18,20-24H2,(H,37,45)(H,38,40)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair