null

SMILES: CC1CN(CC(C)O1)C1CCN(CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC(F)(F)F)cc1

InChI Key: InChIKey=UYOFPZQMLBOVKX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366863   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM366863 (1-[4-[2-[4-[4-(2,6- dimethylmorpholin-4- yl)piperi...) Show SMILES CC1CN(CC(C)O1)C1CCN(CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC(F)(F)F)cc1 |t:34| Show InChI InChI=1S/C33H40F3N7O3/c1-22-20-42(21-23(2)46-22)27-12-18-41(19-13-27)31(45)25-5-7-26(8-6-25)37-32-38-30-28(4-3-15-43(30)39-32)24-10-16-40(17-11-24)29(44)9-14-33(34,35)36/h3-8,10,15,22-23,27H,9,11-14,16-21H2,1-2H3,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM366863 (1-[4-[2-[4-[4-(2,6- dimethylmorpholin-4- yl)piperi...) Show SMILES CC1CN(CC(C)O1)C1CCN(CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC(F)(F)F)cc1 |t:34| Show InChI InChI=1S/C33H40F3N7O3/c1-22-20-42(21-23(2)46-22)27-12-18-41(19-13-27)31(45)25-5-7-26(8-6-25)37-32-38-30-28(4-3-15-43(30)39-32)24-10-16-40(17-11-24)29(44)9-14-33(34,35)36/h3-8,10,15,22-23,27H,9,11-14,16-21H2,1-2H3,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.710	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2CC130F
					More data for this Ligand-Target Pair