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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM366863'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM366863
PNG
(1-[4-[2-[4-[4-(2,6- dimethylmorpholin-4- yl)piperi...)
Show SMILES CC1CN(CC(C)O1)C1CCN(CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC(F)(F)F)cc1 |t:34|
Show InChI InChI=1S/C33H40F3N7O3/c1-22-20-42(21-23(2)46-22)27-12-18-41(19-13-27)31(45)25-5-7-26(8-6-25)37-32-38-30-28(4-3-15-43(30)39-32)24-10-16-40(17-11-24)29(44)9-14-33(34,35)36/h3-8,10,15,22-23,27H,9,11-14,16-21H2,1-2H3,(H,37,39)
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US Patent
 0.270n/an/an/an/an/an/an/an/a



Duquesne University



Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2CC130F
More data for this
Ligand-Target Pair