null

SMILES: COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3F)c2cc1OCCOC

InChI Key: InChIKey=YSGPBAOLVZQBDU-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368999   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM368999 (N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3-...) Show SMILES COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3F)c2cc1OCCOC Show InChI InChI=1S/C23H26FN3O6S/c1-30-7-9-32-21-12-18-20(13-22(21)33-10-8-31-2)25-14-26-23(18)17-6-3-15(11-19(17)24)27-34(28,29)16-4-5-16/h3,6,11-14,16,27H,4-5,7-10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universitàadi Roma					Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...				J Med Chem 51: 1560-76 (2008) BindingDB Entry DOI: 10.7270/Q2HX1FZW
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM368999 (N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3-...) Show SMILES COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3F)c2cc1OCCOC Show InChI InChI=1S/C23H26FN3O6S/c1-30-7-9-32-21-12-18-20(13-22(21)33-10-8-31-2)25-14-26-23(18)17-6-3-15(11-19(17)24)27-34(28,29)16-4-5-16/h3,6,11-14,16,27H,4-5,7-10H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.05E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza Universitàadi Roma					Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...				J Med Chem 51: 1560-76 (2008) BindingDB Entry DOI: 10.7270/Q2HX1FZW
					More data for this Ligand-Target Pair