BDBM386057 4-(4-(1-(4-chloro-3-fluorophenyl)-2-(methylamino)ethyl)piperazin-1-yl)-7,8-dihydropteridin-6(5H)-one::US10287300, Compound A59
SMILES: CNCC(N1CCN(CC1)c1ncnc2NCC(=O)Nc12)c1ccc(Cl)c(F)c1
InChI Key: InChIKey=ATXUMKFIWMTCKC-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proline-rich AKT1 substrate 1 (Homo sapiens (Human)) | BDBM386057 (4-(4-(1-(4-chloro-3-fluorophenyl)-2-(methylamino)e...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison | Assay Description A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... | J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q26M394B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-1 [T412E] (Homo sapiens (Human)) | BDBM386057 (4-(4-(1-(4-chloro-3-fluorophenyl)-2-(methylamino)e...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison | Assay Description P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... | J Med Chem 51: 7243-52 (2008) BindingDB Entry DOI: 10.7270/Q26M394B | |||||||||||
More data for this Ligand-Target Pair |