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Found 1 hit Enz. Inhib. hit(s) with Target = 'Proline-rich AKT1 substrate 1' and Ligand = 'BDBM386057'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proline-rich AKT1 substrate 1


(Homo sapiens (Human))		BDBM386057
PNG
(4-(4-(1-(4-chloro-3-fluorophenyl)-2-(methylamino)e...)
Show SMILES CNCC(N1CCN(CC1)c1ncnc2NCC(=O)Nc12)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C19H23ClFN7O/c1-22-9-15(12-2-3-13(20)14(21)8-12)27-4-6-28(7-5-27)19-17-18(24-11-25-19)23-10-16(29)26-17/h2-3,8,11,15,22H,4-7,9-10H2,1H3,(H,26,29)(H,23,24,25)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



University of Wisconsin at Madison



Assay Description
A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...

J Med Chem 51: 7243-52 (2008)


BindingDB Entry DOI: 10.7270/Q26M394B
More data for this
Ligand-Target Pair