BDBM395255 (4aR,5aR or 4aS,5aS)-5a-Methyl-3-(phenylamino)-2-(pyridin-4-yl)-4a,5,5a,6-tetrahydrocyclopropa[f]indol-4(1H)-one::US10308629, Example 17

SMILES: C[C@]12C[C@H]1C(=O)c1c(C2)[nH]c(c1Nc1ccccc1)-c1ccncc1

InChI Key:

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 395255   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitotic checkpoint serine/threonine-protein kinase BUB1 (Homo sapiens (Human))	BDBM395255 ((4aR,5aR or 4aS,5aS)-5a-Methyl-3-(phenylamino)-2-(...) Show SMILES C[C@]12C[C@H]1C(=O)c1c(C2)[nH]c(c1Nc1ccccc1)-c1ccncc1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...				Bioorg Med Chem Lett 19: 3674-8 (2009) BindingDB Entry DOI: 10.7270/Q2NZ89ZG
					More data for this Ligand-Target Pair