BDBM397894 US9994552, Compound 105

SMILES: COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CNCCO1

InChI Key: InChIKey=IISKUFHJBAJAGW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 397894   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Kit (Kit)(D816V) (Homo sapiens (Human))	BDBM397894 (US9994552, Compound 105) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CNCCO1 Show InChI InChI=1S/C29H33N7O3/c1-37-26-15-25-24(14-27(26)39-19-23-18-30-7-12-38-23)28(34-20-33-25)35-8-10-36(11-9-35)29-31-16-22(17-32-29)13-21-5-3-2-4-6-21/h2-6,14-17,20,23,30H,7-13,18-19H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM397894 (US9994552, Compound 105) Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CNCCO1 Show InChI InChI=1S/C29H33N7O3/c1-37-26-15-25-24(14-27(26)39-19-23-18-30-7-12-38-23)28(34-20-33-25)35-8-10-36(11-9-35)29-31-16-22(17-32-29)13-21-5-3-2-4-6-21/h2-6,14-17,20,23,30H,7-13,18-19H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...				J Med Chem 52: 4892-902 (2009) BindingDB Entry DOI: 10.7270/Q27M0B8Q
					More data for this Ligand-Target Pair