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SMILES: Clc1ccc(cc1)-c1c(nn2CCCOc12)C(=O)N1CCC1

InChI Key: InChIKey=BKTUIOVWODWFPG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 399942   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM399942 (US10323042, Example 22 | US10738063, Example 22) Show SMILES Clc1ccc(cc1)-c1c(nn2CCCOc12)C(=O)N1CCC1 Show InChI InChI=1S/C16H16ClN3O2/c17-12-5-3-11(4-6-12)13-14(15(21)19-7-1-8-19)18-20-9-2-10-22-16(13)20/h3-6H,1-2,7-10H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	483	n/a	n/a	n/a	n/a	n/a	n/a
CNR					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				J Med Chem 52: 5990-8 (2009) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
Isoform 7 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A8) (Homo sapiens (Human))	BDBM399942 (US10323042, Example 22 | US10738063, Example 22) Show SMILES Clc1ccc(cc1)-c1c(nn2CCCOc12)C(=O)N1CCC1 Show InChI InChI=1S/C16H16ClN3O2/c17-12-5-3-11(4-6-12)13-14(15(21)19-7-1-8-19)18-20-9-2-10-22-16(13)20/h3-6H,1-2,7-10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	877	n/a	n/a	n/a	n/a	n/a	n/a
CNR					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				J Med Chem 52: 5990-8 (2009) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Homo sapiens (Human))	BDBM399942 (US10323042, Example 22 | US10738063, Example 22) Show SMILES Clc1ccc(cc1)-c1c(nn2CCCOc12)C(=O)N1CCC1 Show InChI InChI=1S/C16H16ClN3O2/c17-12-5-3-11(4-6-12)13-14(15(21)19-7-1-8-19)18-20-9-2-10-22-16(13)20/h3-6H,1-2,7-10H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	977	n/a	n/a	n/a	n/a	n/a	n/a
CNR					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				J Med Chem 52: 5990-8 (2009) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) 0-562] (Homo sapiens (Human))	BDBM399942 (US10323042, Example 22 | US10738063, Example 22) Show SMILES Clc1ccc(cc1)-c1c(nn2CCCOc12)C(=O)N1CCC1 Show InChI InChI=1S/C16H16ClN3O2/c17-12-5-3-11(4-6-12)13-14(15(21)19-7-1-8-19)18-20-9-2-10-22-16(13)20/h3-6H,1-2,7-10H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description A portion of the human PDE4D3 coding sequence (amino acids 50 to 672 from the sequence with accession number Q08499-2) was cloned into the baculoviru...				US Patent US10738063 (2020) BindingDB Entry DOI: 10.7270/Q20Z76BW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736] (Homo sapiens (Human))	BDBM399942 (US10323042, Example 22 | US10738063, Example 22) Show SMILES Clc1ccc(cc1)-c1c(nn2CCCOc12)C(=O)N1CCC1 Show InChI InChI=1S/C16H16ClN3O2/c17-12-5-3-11(4-6-12)13-14(15(21)19-7-1-8-19)18-20-9-2-10-22-16(13)20/h3-6H,1-2,7-10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	483	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Human PDE4B1 coding sequence (amino acids 122 to 736 from the sequence with accession number Q07343) with the mutations resulting in the amino acid s...				US Patent US10738063 (2020) BindingDB Entry DOI: 10.7270/Q20Z76BW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825] (Homo sapiens (Human))	BDBM399942 (US10323042, Example 22 | US10738063, Example 22) Show SMILES Clc1ccc(cc1)-c1c(nn2CCCOc12)C(=O)N1CCC1 Show InChI InChI=1S/C16H16ClN3O2/c17-12-5-3-11(4-6-12)13-14(15(21)19-7-1-8-19)18-20-9-2-10-22-16(13)20/h3-6H,1-2,7-10H2	PDB MMDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	877	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...				US Patent US10738063 (2020) BindingDB Entry DOI: 10.7270/Q20Z76BW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C [2-712] ()	BDBM399942 (US10323042, Example 22 | US10738063, Example 22) Show SMILES Clc1ccc(cc1)-c1c(nn2CCCOc12)C(=O)N1CCC1 Show InChI InChI=1S/C16H16ClN3O2/c17-12-5-3-11(4-6-12)13-14(15(21)19-7-1-8-19)18-20-9-2-10-22-16(13)20/h3-6H,1-2,7-10H2	PDB MMDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	977	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Human PDE4C1 coding sequence (amino acids 2 to 712 from the sequence with accession number NP_000914.2) was cloned into the baculovirus expression ve...				US Patent US10738063 (2020) BindingDB Entry DOI: 10.7270/Q20Z76BW
					More data for this Ligand-Target Pair
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) (Homo sapiens (Human))	BDBM399942 (US10323042, Example 22 | US10738063, Example 22) Show SMILES Clc1ccc(cc1)-c1c(nn2CCCOc12)C(=O)N1CCC1 Show InChI InChI=1S/C16H16ClN3O2/c17-12-5-3-11(4-6-12)13-14(15(21)19-7-1-8-19)18-20-9-2-10-22-16(13)20/h3-6H,1-2,7-10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
CNR					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				J Med Chem 52: 5990-8 (2009) BindingDB Entry DOI: 10.7270/Q2NP26RH
					More data for this Ligand-Target Pair