BDBM426311 US10513524, Compound (P1)
SMILES: Fc1ccc(cc1)-c1ncc2n1nc(CN1CC(C1)Oc1ccncc1)[nH]c2=O
InChI Key: InChIKey=KCDCTXKHLQKROY-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human)) | BDBM426311 (US10513524, Compound (P1)) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
H. LUNDBECK A/S US Patent | Assay Description PDE1 assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 (sufficient to con... | US Patent US10513524 (2019) BindingDB Entry DOI: 10.7270/Q2G44SNW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM426311 (US10513524, Compound (P1)) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
H. LUNDBECK A/S US Patent | Assay Description A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (... | US Patent US10513524 (2019) BindingDB Entry DOI: 10.7270/Q2G44SNW | |||||||||||
More data for this Ligand-Target Pair |