BDBM448216 US10689399, Compound 100

SMILES: Fc1ccc(F)c(CNC(=O)c2cn3CC4C5CCC(C5)N4C(=O)c3cc2=O)c1

InChI Key: InChIKey=WFXWVTYMIRYPOR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 448216   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
POU domain, class 2, transcription factor 2 (Homo sapiens (Human))	BDBM448216 (US10689399, Compound 100) Show SMILES Fc1ccc(F)c(CNC(=O)c2cn3CC4C5CCC(C5)N4C(=O)c3cc2=O)c1 |THB:14:15:18.17:20,22:21:18.17:20| Show InChI InChI=1S/C21H19F2N3O3/c22-13-2-4-16(23)12(5-13)8-24-20(28)15-9-25-10-18-11-1-3-14(6-11)26(18)21(29)17(25)7-19(15)27/h2,4-5,7,9,11,14,18H,1,3,6,8,10H2,(H,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...				US Patent US10689399 (2020)
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