BDBM453124 US10711036, Compound 174

SMILES: CC(C)[C@H](NC(=O)c1ccc(Br)cc1)C(=O)N1COC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)CF

InChI Key: InChIKey=PGLZAAFBGUBOEE-LNLFQRSKSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 453124   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM453124 (US10711036, Compound 174) Show SMILES CC(C)[C@H](NC(=O)c1ccc(Br)cc1)C(=O)N1COC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)CF |r| Show InChI InChI=1S/C23H32BrFN6O5/c1-13(2)19(30-20(33)14-5-7-15(24)8-6-14)22(35)31-12-36-11-17(31)21(34)29-16(18(32)10-25)4-3-9-28-23(26)27/h5-8,13,16-17,19H,3-4,9-12H2,1-2H3,(H,29,34)(H,30,33)(H4,26,27,28)/t16-,17-,19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cornell University; Dana-Farber Cancer Institute, Inc.; Children''s Medical Center Corporation US Patent					Assay Description For exemplary compounds of the disclosure, Ki for inhibition of MALT1 was measured (Table E11). A concentration of 100 nM MALT1 was used for the assa...				US Patent US10711036 (2020)
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