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SMILES: C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cc2nc1-c1ccccn1

InChI Key: InChIKey=GSBDNUCRKFRWBU-NSHDSACASA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464392   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM464392
PNG
(US10792283, Compound 2)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cc2nc1-c1ccccn1
Show InChI InChI=1S/C21H17FN8/c1-11(27-20-15(10-23)19(24)29-21(25)30-20)14-8-12-5-6-13(22)9-17(12)28-18(14)16-4-2-3-7-26-16/h2-9,11H,1H3,(H5,24,25,27,29,30)/t11-/m0/s1
PDB
MMDB

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KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0860n/an/an/an/an/an/a



HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Enzymatic activity of the class I PI3K isoforms in the presence of the compounds of Table 1 above was measured using a time-resolved fluorescence res...

US Patent US10792283 (2020)


BindingDB Entry DOI: 10.7270/Q2ZK5KQH
More data for this
Ligand-Target Pair