BDBM481137 US10906896, Cpd 8190

SMILES: CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncc(c3)-c3cc(C)ns3)c2)CC1

InChI Key: InChIKey=PKDOQGUKLRAMEF-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 481137   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM481137 (US10906896, Cpd 8190) Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncc(c3)-c3cc(C)ns3)c2)CC1 Show InChI InChI=1S/C33H34N8OS/c1-22-4-9-28(36-32(42)25-7-5-24(6-8-25)21-41-14-12-40(3)13-15-41)18-30(22)38-33-35-11-10-29(37-33)26-17-27(20-34-19-26)31-16-23(2)39-43-31/h4-11,16-20H,12-15,21H2,1-3H3,(H,36,42)(H,35,37,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Inhibikase Therapeutics, Inc. US Patent					Assay Description Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl2 2 mM DTT) and Stop buffer, (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Re...				US Patent US10906896 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM481137 (US10906896, Cpd 8190) Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncc(c3)-c3cc(C)ns3)c2)CC1 Show InChI InChI=1S/C33H34N8OS/c1-22-4-9-28(36-32(42)25-7-5-24(6-8-25)21-41-14-12-40(3)13-15-41)18-30(22)38-33-35-11-10-29(37-33)26-17-27(20-34-19-26)31-16-23(2)39-43-31/h4-11,16-20H,12-15,21H2,1-3H3,(H,36,42)(H,35,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
Inhibikase Therapeutics, Inc. US Patent					Assay Description Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl2 2 mM DTT) and Stop buffer, (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Re...				US Patent US10906896 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL2 (Homo sapiens (Human))	BDBM481137 (US10906896, Cpd 8190) Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncc(c3)-c3cc(C)ns3)c2)CC1 Show InChI InChI=1S/C33H34N8OS/c1-22-4-9-28(36-32(42)25-7-5-24(6-8-25)21-41-14-12-40(3)13-15-41)18-30(22)38-33-35-11-10-29(37-33)26-17-27(20-34-19-26)31-16-23(2)39-43-31/h4-11,16-20H,12-15,21H2,1-3H3,(H,36,42)(H,35,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
Inhibikase Therapeutics, Inc. US Patent					Assay Description Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl2 2 mM DTT) and Stop buffer, (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Re...				US Patent US10906896 (2021)
					More data for this Ligand-Target Pair