BDBM49152 5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-yl-methyl]quinolin-8-ol::5-chloro-7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinol::5-chloro-7-[(4-ethylpiperazin-1-yl)-pyridin-3-ylmethyl]quinolin-8-ol::5-chloro-7-[(4-ethylpiperazino)-(3-pyridyl)methyl]quinolin-8-ol::BRD4354::MLS000564806::SMR000151966::cid_3516032

SMILES: CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O

InChI Key: InChIKey=XAFSFXYJOJWLJD-UHFFFAOYSA-N

Data: 11 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 49152   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor beta (Homo sapiens (Human))	BDBM49152 (5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...) Show SMILES CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O Show InChI InChI=1S/C21H23ClN4O/c1-2-25-9-11-26(12-10-25)20(15-5-3-7-23-14-15)17-13-18(22)16-6-4-8-24-19(16)21(17)27/h3-8,13-14,20,27H,2,9-12H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	2.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Molecular Libraries Screening Center Curated by PubChem BioAssay					Assay Description NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2CF9NHH
					More data for this Ligand-Target Pair
Neutrophil cytosol factor 1 [S99G] (Homo sapiens (Human))	BDBM49152 (5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...) Show SMILES CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O Show InChI InChI=1S/C21H23ClN4O/c1-2-25-9-11-26(12-10-25)20(15-5-3-7-23-14-15)17-13-18(22)16-6-4-8-24-19(16)21(17)27/h3-8,13-14,20,27H,2,9-12H2,1H3	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Molecular Libraries Screening Center Curated by PubChem BioAssay					Assay Description NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Susan Smith, Emory Univers...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2M90723
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Mus musculus)	BDBM49152 (5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...) Show SMILES CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O Show InChI InChI=1S/C21H23ClN4O/c1-2-25-9-11-26(12-10-25)20(15-5-3-7-23-14-15)17-13-18(22)16-6-4-8-24-19(16)21(17)27/h3-8,13-14,20,27H,2,9-12H2,1H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	>1.95E+5	n/a	n/a	n/a	n/a
Broad Institute Curated by PubChem BioAssay					Assay Description Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2MW2FKX
					More data for this Ligand-Target Pair
Mitochondrial import inner membrane translocase subunit TIM10 (Saccharomyces cerevisiae S288c)	BDBM49152 (5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...) Show SMILES CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O Show InChI InChI=1S/C21H23ClN4O/c1-2-25-9-11-26(12-10-25)20(15-5-3-7-23-14-15)17-13-18(22)16-6-4-8-24-19(16)21(17)27/h3-8,13-14,20,27H,2,9-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2F18X6W
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM49152 (5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...) Show SMILES CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O Show InChI InChI=1S/C21H23ClN4O/c1-2-25-9-11-26(12-10-25)20(15-5-3-7-23-14-15)17-13-18(22)16-6-4-8-24-19(16)21(17)27/h3-8,13-14,20,27H,2,9-12H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.04E+4	n/a	n/a	n/a	n/a	7.4	n/a
Broad Institute					Assay Description Briefly, this fluorogenic assays uses an acetylated lysine tripeptide substrate, amide-linked to a fluorescently quenched aminocoumarin (AMC). Enzyme...				ACS Chem Biol 11: 1844-51 (2016) Article DOI: 10.1021/acschembio.6b00012 BindingDB Entry DOI: 10.7270/Q2QF8RPQ
					More data for this Ligand-Target Pair
Histone deacetylase 9 (Homo sapiens (Human))	BDBM49152 (5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...) Show SMILES CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O Show InChI InChI=1S/C21H23ClN4O/c1-2-25-9-11-26(12-10-25)20(15-5-3-7-23-14-15)17-13-18(22)16-6-4-8-24-19(16)21(17)27/h3-8,13-14,20,27H,2,9-12H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.88E+3	n/a	n/a	n/a	n/a	7.4	n/a
Broad Institute					Assay Description Briefly, this fluorogenic assays uses an acetylated lysine tripeptide substrate, amide-linked to a fluorescently quenched aminocoumarin (AMC). Enzyme...				ACS Chem Biol 11: 1844-51 (2016) Article DOI: 10.1021/acschembio.6b00012 BindingDB Entry DOI: 10.7270/Q2QF8RPQ
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM49152 (5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...) Show SMILES CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O Show InChI InChI=1S/C21H23ClN4O/c1-2-25-9-11-26(12-10-25)20(15-5-3-7-23-14-15)17-13-18(22)16-6-4-8-24-19(16)21(17)27/h3-8,13-14,20,27H,2,9-12H2,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.51E+4	n/a	n/a	n/a	n/a	7.4	n/a
Broad Institute					Assay Description Briefly, this fluorogenic assays uses an acetylated lysine tripeptide substrate, amide-linked to a fluorescently quenched aminocoumarin (AMC). Enzyme...				ACS Chem Biol 11: 1844-51 (2016) Article DOI: 10.1021/acschembio.6b00012 BindingDB Entry DOI: 10.7270/Q2QF8RPQ
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Homo sapiens (Human))	BDBM49152 (5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...) Show SMILES CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O Show InChI InChI=1S/C21H23ClN4O/c1-2-25-9-11-26(12-10-25)20(15-5-3-7-23-14-15)17-13-18(22)16-6-4-8-24-19(16)21(17)27/h3-8,13-14,20,27H,2,9-12H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.38E+4	n/a	n/a	n/a	n/a	7.4	n/a
Broad Institute					Assay Description Briefly, this fluorogenic assays uses an acetylated lysine tripeptide substrate, amide-linked to a fluorescently quenched aminocoumarin (AMC). Enzyme...				ACS Chem Biol 11: 1844-51 (2016) Article DOI: 10.1021/acschembio.6b00012 BindingDB Entry DOI: 10.7270/Q2QF8RPQ
					More data for this Ligand-Target Pair
Histone deacetylase 5 (Homo sapiens (Human))	BDBM49152 (5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...) Show SMILES CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O Show InChI InChI=1S/C21H23ClN4O/c1-2-25-9-11-26(12-10-25)20(15-5-3-7-23-14-15)17-13-18(22)16-6-4-8-24-19(16)21(17)27/h3-8,13-14,20,27H,2,9-12H2,1H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	7.4	n/a
Broad Institute					Assay Description Briefly, this fluorogenic assays uses an acetylated lysine tripeptide substrate, amide-linked to a fluorescently quenched aminocoumarin (AMC). Enzyme...				ACS Chem Biol 11: 1844-51 (2016) Article DOI: 10.1021/acschembio.6b00012 BindingDB Entry DOI: 10.7270/Q2QF8RPQ
					More data for this Ligand-Target Pair
Histone deacetylase 7 (Homo sapiens (Human))	BDBM49152 (5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...) Show SMILES CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O Show InChI InChI=1S/C21H23ClN4O/c1-2-25-9-11-26(12-10-25)20(15-5-3-7-23-14-15)17-13-18(22)16-6-4-8-24-19(16)21(17)27/h3-8,13-14,20,27H,2,9-12H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.44E+3	n/a	n/a	n/a	n/a	7.4	n/a
Broad Institute					Assay Description Briefly, this fluorogenic assays uses an acetylated lysine tripeptide substrate, amide-linked to a fluorescently quenched aminocoumarin (AMC). Enzyme...				ACS Chem Biol 11: 1844-51 (2016) Article DOI: 10.1021/acschembio.6b00012 BindingDB Entry DOI: 10.7270/Q2QF8RPQ
					More data for this Ligand-Target Pair
Histone deacetylase 8 [R223M] (Homo sapiens (Human))	BDBM49152 (5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...) Show SMILES CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O Show InChI InChI=1S/C21H23ClN4O/c1-2-25-9-11-26(12-10-25)20(15-5-3-7-23-14-15)17-13-18(22)16-6-4-8-24-19(16)21(17)27/h3-8,13-14,20,27H,2,9-12H2,1H3	PDB GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.89E+3	n/a	n/a	n/a	n/a	7.4	n/a
Broad Institute					Assay Description Briefly, this fluorogenic assays uses an acetylated lysine tripeptide substrate, amide-linked to a fluorescently quenched aminocoumarin (AMC). Enzyme...				ACS Chem Biol 11: 1844-51 (2016) Article DOI: 10.1021/acschembio.6b00012 BindingDB Entry DOI: 10.7270/Q2QF8RPQ
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM49152 (5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-y...) Show SMILES CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O Show InChI InChI=1S/C21H23ClN4O/c1-2-25-9-11-26(12-10-25)20(15-5-3-7-23-14-15)17-13-18(22)16-6-4-8-24-19(16)21(17)27/h3-8,13-14,20,27H,2,9-12H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.72E+4	n/a	n/a	n/a	n/a	7.4	n/a
Broad Institute					Assay Description Briefly, this fluorogenic assays uses an acetylated lysine tripeptide substrate, amide-linked to a fluorescently quenched aminocoumarin (AMC). Enzyme...				ACS Chem Biol 11: 1844-51 (2016) Article DOI: 10.1021/acschembio.6b00012 BindingDB Entry DOI: 10.7270/Q2QF8RPQ
					More data for this Ligand-Target Pair