BindingDB PrimarySearch

BDBM50000663 (+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(+)-MK-801::(+)MK-801::(+/-) MK-8011-methyl-(9R,1R)-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(+/-)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(+/-)-MK801::(-)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(-)-MK801::(1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0^{2,7}.0^{10,15}]hexadeca-2(7),3,5,10(15),11,13-hexaene::(1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0^{2,7}.0^{10,15}]hexadeca-2,4,6,10(15),11,13-hexaene::(5S,10R)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]cyclohepten-5,10-imine::(5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]cyclohepten-5,10-imine::(Dizocilpine)1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(MK-801)1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene(MK-801)::1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10,12,14-hexaene::1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10(15),11,13-hexaene::10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine.(MK-801)::CHEMBL284237::MK-801::MK-801 (Dizocilpine)::MK-801,(+)::MK-801,(-)::dizocilpine

SMILES: C[C@]12NC(Cc3ccccc13)c1ccccc21

InChI Key: InChIKey=LBOJYSIDWZQNJS-LYKKTTPLSA-N

Data: 16 KI 1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50000663
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Co. GmbH & Co. Curated by PDSP K_i Database									Neuropharmacology 34: 533-40 (1995) Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F
Merz Co. GmbH & Co. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Co. GmbH & Co. Curated by PDSP K_i Database									Neuropharmacology 34: 533-40 (1995) Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F
Merz Co. GmbH & Co. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	8.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Co. GmbH & Co. Curated by PDSP K_i Database									Neuropharmacology 34: 533-40 (1995) Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F
Merz Co. GmbH & Co. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	8.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Co. GmbH & Co. Curated by PDSP K_i Database									Neuropharmacology 34: 533-40 (1995) Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F
Merz Co. GmbH & Co. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	9.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Co. GmbH & Co. Curated by PDSP K_i Database									Neuropharmacology 34: 533-40 (1995) Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F
Merz Co. GmbH & Co. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	10.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Co. GmbH & Co. Curated by PDSP K_i Database									Neuropharmacology 34: 533-40 (1995) Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F
Merz Co. GmbH & Co. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	13.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Co. GmbH & Co. Curated by PDSP K_i Database									Neuropharmacology 34: 533-40 (1995) Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F
Merz Co. GmbH & Co. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	20.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Co. GmbH & Co. Curated by PDSP K_i Database									Neuropharmacology 34: 533-40 (1995) Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F
Merz Co. GmbH & Co. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	24.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Co. GmbH & Co. Curated by PDSP K_i Database									Neuropharmacology 34: 533-40 (1995) Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F
Merz Co. GmbH & Co. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	27.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Co. GmbH & Co. Curated by PDSP K_i Database									Neuropharmacology 34: 533-40 (1995) Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F
Merz Co. GmbH & Co. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	53.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merz Co. GmbH & Co. Curated by PDSP K_i Database									Neuropharmacology 34: 533-40 (1995) Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F
Merz Co. GmbH & Co. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Imidazoline I1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by PDSP K_i Database									J Pharmacol Exp Ther 285: 170-7 (1998) BindingDB Entry DOI: 10.7270/Q27H1H4B
University of Bonn Curated by PDSP K_i Database					More data for this Ligand-Target Pair
GABA(A) receptor subunit alpha-2 (Rattus norvegicus (Rat))	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	4.09E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Tested for invitro inhibition of the displacement of [3H]-mazindol from GABA receptor				J Med Chem 36: 2499-507 (1993) BindingDB Entry DOI: 10.7270/Q2V69HNK
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.92E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Tested for invitro inhibition of the displacement of (+)-[3H]-pentazocine from sigma opioid receptor				J Med Chem 36: 2499-507 (1993) BindingDB Entry DOI: 10.7270/Q2V69HNK
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Tested for invitro inhibition of the displacement of [3H]-FOXY from mu opioid receptor				J Med Chem 36: 2499-507 (1993) BindingDB Entry DOI: 10.7270/Q2V69HNK
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor (RAT)	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Tested for in vitro inhibition of the displacement of [3H]QNB from CNS receptor				J Med Chem 36: 2499-507 (1993) BindingDB Entry DOI: 10.7270/Q2V69HNK
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human))	BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) Show SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	6.9	n/a
Medical University of Lublin Curated by ChEMBL					Assay Description Antagonist activity at NR1/2B receptor (unknown origin) expressed in xenopus laevis at pH 6.9 by two electrode voltage clamp method				J Med Chem 51: 3765-76 (2008) Article DOI: 10.1021/jm7011694 BindingDB Entry DOI: 10.7270/Q21Z447W
Medical University of Lublin Curated by ChEMBL					More data for this Ligand-Target Pair