BDBM50002823 2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan-2-yl]-benzenesulfonyl}-ethanol::CHEMBL299944::L-680573::MK-287
SMILES: CCCOc1c(OC)cc(cc1S(=O)(=O)CCO)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
InChI Key: InChIKey=WXIDMVGKJBAEFP-OALUTQOASA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Platelet activating factor receptor (Homo sapiens (Human)) | BDBM50002823 (2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to human platelet | Bioorg Med Chem Lett 1: 327-332 (1991) Article DOI: 10.1016/S0960-894X(01)80818-0 BindingDB Entry DOI: 10.7270/Q2TM7BKP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet activating factor receptor (Homo sapiens (Human)) | BDBM50002823 (2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation | J Med Chem 35: 3474-82 (1992) BindingDB Entry DOI: 10.7270/Q2445N3B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet activating factor receptor (Homo sapiens (Human)) | BDBM50002823 (2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor was determined | Bioorg Med Chem Lett 2: 181-184 (1992) Article DOI: 10.1016/S0960-894X(01)80446-7 BindingDB Entry DOI: 10.7270/Q24X588Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet activating factor receptor (Homo sapiens (Human)) | BDBM50002823 (2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to PMN membrane receptors | Bioorg Med Chem Lett 1: 327-332 (1991) Article DOI: 10.1016/S0960-894X(01)80818-0 BindingDB Entry DOI: 10.7270/Q2TM7BKP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet activating factor receptor (Homo sapiens (Human)) | BDBM50002823 (2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation | J Med Chem 35: 3474-82 (1992) BindingDB Entry DOI: 10.7270/Q2445N3B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet activating factor receptor (Cavia porcellus) | BDBM50002823 (2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...) | MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand | J Med Chem 37: 2011-32 (1994) BindingDB Entry DOI: 10.7270/Q2GH9JM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet activating factor receptor (Homo sapiens (Human)) | BDBM50002823 (2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to human platelet | Bioorg Med Chem Lett 1: 327-332 (1991) Article DOI: 10.1016/S0960-894X(01)80818-0 BindingDB Entry DOI: 10.7270/Q2TM7BKP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet activating factor receptor (Homo sapiens (Human)) | BDBM50002823 (2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 116 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to human platelet | Bioorg Med Chem Lett 1: 327-332 (1991) Article DOI: 10.1016/S0960-894X(01)80818-0 BindingDB Entry DOI: 10.7270/Q2TM7BKP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet activating factor receptor (Homo sapiens (Human)) | BDBM50002823 (2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Displacement of [3H]-PAF from PAF receptor of human platelet membranes | J Med Chem 41: 1970-9 (1998) Article DOI: 10.1021/jm980046r BindingDB Entry DOI: 10.7270/Q2PV6JH2 | |||||||||||
More data for this Ligand-Target Pair |