BDBM50005734 2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-propylamino]-3-methoxy-benzoylamino}-pentanedioic acid::CHEMBL29713

SMILES: COc1cc(ccc1NCCCc1c(N)nc(N)[nH]c1=O)C(=O)NC(CCC(O)=O)C(O)=O

InChI Key: InChIKey=FZVNPRJLVNYBCI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50005734   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycinamide ribonucleotide formyltransferase (GARFTase) (Homo sapiens (Human))	BDBM50005734 (2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5...) Show SMILES COc1cc(ccc1NCCCc1c(N)nc(N)[nH]c1=O)C(=O)NC(CCC(O)=O)C(O)=O Show InChI InChI=1S/C20H26N6O7/c1-33-14-9-10(17(29)24-13(19(31)32)6-7-15(27)28)4-5-12(14)23-8-2-3-11-16(21)25-20(22)26-18(11)30/h4-5,9,13,23H,2-3,6-8H2,1H3,(H,24,29)(H,27,28)(H,31,32)(H5,21,22,25,26,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.87E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wellcome Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of hog liver GAR transformylase with (6R)-10-formyl-FH4 as cofactor				J Med Chem 35: 1399-410 (1992) BindingDB Entry DOI: 10.7270/Q20R9NBZ
					More data for this Ligand-Target Pair