BDBM50006580 1-Methyl-5-(4-methylsulfanyl-[1,2,5]thiadiazol-3-yl)-1,2,3,6-tetrahydro-pyridine; oxalic acid::CHEMBL15944::CHEMBL308608

SMILES: CSc1nsnc1C1=CCCN(C)C1

InChI Key: InChIKey=SGQUZSYRIZOLFQ-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50006580   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50006580 (1-Methyl-5-(4-methylsulfanyl-[1,2,5]thiadiazol-3-y...) Show SMILES CSc1nsnc1C1=CCCN(C)C1 |t:8| Show InChI InChI=1S/C9H13N3S2/c1-12-5-3-4-7(6-12)8-9(13-2)11-14-10-8/h4H,3,5-6H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk CNS Division Curated by ChEMBL					Assay Description In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-oxotremorine-M (Oxo-M) as radioligand				J Med Chem 35: 2274-83 (1992) BindingDB Entry DOI: 10.7270/Q22J69TH
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50006580 (1-Methyl-5-(4-methylsulfanyl-[1,2,5]thiadiazol-3-y...) Show SMILES CSc1nsnc1C1=CCCN(C)C1 |t:8| Show InChI InChI=1S/C9H13N3S2/c1-12-5-3-4-7(6-12)8-9(13-2)11-14-10-8/h4H,3,5-6H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk CNS Division Curated by ChEMBL					Assay Description In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligand				J Med Chem 35: 2274-83 (1992) BindingDB Entry DOI: 10.7270/Q22J69TH
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50006580 (1-Methyl-5-(4-methylsulfanyl-[1,2,5]thiadiazol-3-y...) Show SMILES CSc1nsnc1C1=CCCN(C)C1 |t:8| Show InChI InChI=1S/C9H13N3S2/c1-12-5-3-4-7(6-12)8-9(13-2)11-14-10-8/h4H,3,5-6H2,1-2H3	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [3H]-N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetylc...				J Med Chem 41: 109-16 (1998) Article DOI: 10.1021/jm9705216 BindingDB Entry DOI: 10.7270/Q2BV7FQS
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50006580 (1-Methyl-5-(4-methylsulfanyl-[1,2,5]thiadiazol-3-y...) Show SMILES CSc1nsnc1C1=CCCN(C)C1 |t:8| Show InChI InChI=1S/C9H13N3S2/c1-12-5-3-4-7(6-12)8-9(13-2)11-14-10-8/h4H,3,5-6H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [3H]-N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetylc...				J Med Chem 41: 109-16 (1998) Article DOI: 10.1021/jm9705216 BindingDB Entry DOI: 10.7270/Q2BV7FQS
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50006580 (1-Methyl-5-(4-methylsulfanyl-[1,2,5]thiadiazol-3-y...) Show SMILES CSc1nsnc1C1=CCCN(C)C1 |t:8| Show InChI InChI=1S/C9H13N3S2/c1-12-5-3-4-7(6-12)8-9(13-2)11-14-10-8/h4H,3,5-6H2,1-2H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [3H]- N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetyl...				J Med Chem 41: 109-16 (1998) Article DOI: 10.1021/jm9705216 BindingDB Entry DOI: 10.7270/Q2BV7FQS
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50006580 (1-Methyl-5-(4-methylsulfanyl-[1,2,5]thiadiazol-3-y...) Show SMILES CSc1nsnc1C1=CCCN(C)C1 |t:8| Show InChI InChI=1S/C9H13N3S2/c1-12-5-3-4-7(6-12)8-9(13-2)11-14-10-8/h4H,3,5-6H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [3H]- N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetyl...				J Med Chem 41: 109-16 (1998) Article DOI: 10.1021/jm9705216 BindingDB Entry DOI: 10.7270/Q2BV7FQS
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50006580 (1-Methyl-5-(4-methylsulfanyl-[1,2,5]thiadiazol-3-y...) Show SMILES CSc1nsnc1C1=CCCN(C)C1 |t:8| Show InChI InChI=1S/C9H13N3S2/c1-12-5-3-4-7(6-12)8-9(13-2)11-14-10-8/h4H,3,5-6H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [3H]- N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetyl...				J Med Chem 41: 109-16 (1998) Article DOI: 10.1021/jm9705216 BindingDB Entry DOI: 10.7270/Q2BV7FQS
					More data for this Ligand-Target Pair